{"product_id":"retatrutide-1","title":"RETATRUTIDE","description":"\u003cp dir=\"auto\"\u003eRetatrutide is an \u003cstrong\u003einvestigational, once-weekly injectable medication\u003c\/strong\u003e developed by Eli Lilly and Company, representing a next-generation advancement in the treatment of obesity and related metabolic conditions. As a \u003cstrong\u003efirst-in-class triple hormone receptor agonist\u003c\/strong\u003e, retatrutide simultaneously activates three key receptors:\u003c\/p\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eGLP-1\u003c\/strong\u003e (glucagon-like peptide-1) receptor — helps regulate appetite, slow gastric emptying, and improve blood sugar control\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGIP\u003c\/strong\u003e (glucose-dependent insulinotropic polypeptide) receptor — enhances insulin secretion and supports metabolic balance\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucagon\u003c\/strong\u003e (GCG) receptor — promotes increased energy expenditure and fat metabolism\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\"\u003eThis unique triple-action mechanism sets retatrutide apart from dual-agonist therapies, enabling synergistic effects on appetite suppression, calorie burning, glycemic control, and overall body composition.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eIn clinical trials, including Phase 2 and the first successful Phase 3 study (TRIUMPH-4), retatrutide has demonstrated substantial results when used alongside a healthy diet and physical activity:\u003c\/p\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003eUp to \u003cstrong\u003e24.2% mean body weight reduction\u003c\/strong\u003e over 48 weeks in Phase 2\u003c\/li\u003e\n\u003cli\u003eUp to \u003cstrong\u003e28.7% average weight loss\u003c\/strong\u003e (equivalent to about 71.2 lbs in some participants) over 68 weeks in Phase 3 among adults with obesity or overweight\u003c\/li\u003e\n\u003cli\u003eAdditional benefits such as reduced liver fat, improved lipid profiles (e.g., lower triglycerides and non-HDL cholesterol), decreased blood pressure, and — in specific populations — significant relief from knee osteoarthritis pain and improved physical function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\"\u003eIn trials, Retatrutide is administered as a subcutaneous injection once per week, with a half-life of approximately 6 days supporting convenient dosing. Common side effects in trials have been primarily gastrointestinal (e.g., nausea, diarrhea), dose-related, and generally mild to moderate, often mitigated with gradual dose escalation.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eCurrently, retatrutide is in ongoing Phase 3 clinical trials (including the TRIUMPH program). Additional data readouts are expected throughout 2026, with potential future availability pending successful completion of studies and regulatory review for indications including obesity, type 2 diabetes, and weight-related complications.\u003c\/p\u003e\n\u003ch4\u003e\u003cspan class=\"s1\"\u003eImportant Notice:\u003c\/span\u003e\u003c\/h4\u003e\n\u003cp class=\"p2\"\u003e\u003cspan class=\"s2\"\u003eThis product is intended \u003c\/span\u003e\u003cspan class=\"s3\"\u003efor \u003cstrong\u003eresearch use only\u003c\/strong\u003e\u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"s2\"\u003e.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cspan class=\"s3\"\u003eNot for\u003cstrong\u003e human \u003c\/strong\u003eor \u003cstrong\u003eanimal\u003c\/strong\u003e use of any kind.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cspan class=\"s3\"\u003eNot a \u003cstrong\u003edrug\u003c\/strong\u003e. Not approved for clinical or therapeutic use.\u003c\/span\u003e\u003c\/p\u003e","brand":"VANTA","offers":[{"title":"10MG","offer_id":53136674226504,"sku":null,"price":99.99,"currency_code":"USD","in_stock":true},{"title":"20MG","offer_id":53136674259272,"sku":null,"price":179.99,"currency_code":"USD","in_stock":true},{"title":"30MG","offer_id":53136674292040,"sku":null,"price":224.99,"currency_code":"USD","in_stock":true},{"title":"60MG","offer_id":53136674324808,"sku":null,"price":359.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0943\/0633\/7096\/files\/RETATRUTIDE_10mg_9c0e298e-3408-4931-a489-9b5686fd7859.jpg?v=1774429814","url":"https:\/\/vanta-peptides.com\/products\/retatrutide-1","provider":"VANTA","version":"1.0","type":"link"}